Lipids and Lipid Derivatives
Medchemexpress LLC Alosetron-d3 hydrochloride | 1189919-71-8 | 99.0% | C17H16D3ClN4O | 5 MG
Alosetron-d3 hydrochloride is a deuterium labeled Alosetron, functioning as a serotonin 5HT3-receptor antagonist. It is suitable for use as a tracer and an internal standard in NMR, GC-MS, or LC-MS analysis for quantitative applications.
- Deuterium labeled compound
- Serotonin 5HT3-receptor antagonist
- Internal standard for quantitative analysis
- Used in neurological disease research
- Supports drug concentration detection
Medchemexpress LLC 1-Methylinosine-d3 | 2140-73-0 | 99.0% | 285.27 | 1 MG
1-Methylinosine-d3 is a deuterium-labeled version of 1-Methylinosine. 1-Methylinosine is a modified nucleotide found at position 37 in the tRNA 3' to the anticodon of eukaryotic tRNA. This product is for research use only.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuterium substitution can affect pharmacokinetic and metabolic profiles.
Medchemexpress LLC Elexacaftor-d3 (VX-445-d3) | 2216712-66-0 | 98.3% | 600.67 | 1 MG
Elexacaftor-d3 (VX-445-d3) is a deuterium labeled compound, serving as a tracer and internal standard for quantitative analysis methods such as NMR, GC-MS, or LC-MS. Deuteration may influence the pharmacokinetic and metabolic profiles of drugs. Its unlabeled counterpart, Elexacaftor (VX-445), acts as a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector, aiming to restore Phe508del CFTR protein function and treat cystic fibrosis.
- Deuterium labeled compound
- Used as a tracer
- Used as an internal standard for quantitative analysis
- Potential to affect pharmacokinetic and metabolic profiles of drugs
- Restores Phe508del CFTR protein function
- Has potential to treat cystic fibrosis
- Improves Phe508del CFTR protein processing, trafficking, and chloride transport
Selleck Chemical LLC Fluorometholone
Fluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye
Medchemexpress LLC Z-guggulsterone | 39025-23-5 | MFCD01310757 | 99.4% | 312.45 g/mol | C21H28O2 | 5 MG
(Z)-Guggulsterone is a plant-derived sterol (CAS 39025-23-5) isolated from Commiphora mukul. It acts as a farnesoid X receptor (FXR) antagonist with reported activities including induction of apoptosis, inhibition of angiogenesis, and modulation of ACE2 expression, and is used in biochemical and cell-signaling research.
- Potent farnesoid X receptor (FXR) antagonist.
- Induces apoptosis in multiple cancer cell lines.
- Inhibits angiogenesis via the VEGF-VEGFR2-Akt pathway.
- Reported to reduce ACE2 expression and SARS-CoV-2 infection in studies.
- Suitable for biochemical and signaling pathway research applications.
Medchemexpress LLC (Z)-Guggulsterone | 39025-23-5 | 99.4% | 312.45 | 10 MG
(Z)-Guggulsterone is a constituent found in the Indian Ayurvedic medicinal plant Commiphora mukul. It functions by inhibiting the growth of human prostate cancer cells through apoptosis and hinders angiogenesis by suppressing the VEGF-VEGF-R2-Akt signaling pathway. It also acts as a potent FXR antagonist, reducing ACE2 expression and inhibiting SARS-CoV-2 infection. This product is intended for research use only and is not sold to patients.
- Inhibits growth of human prostate cancer cells through apoptosis
- Hinders angiogenesis by suppressing VEGF-VEGF-R2-Akt signaling
- Acts as a potent FXR antagonist
- Reduces ACE2 expression
- Inhibits SARS-CoV-2 infection
eMolecules 95975-55-6 | Medchem Express | Guggulsterone | 5mg | 482203886 | HY-107738 | MFCD01310757 | 312.453 | C21H28O2
Medchem Express | Guggulsterone | 5mg | 482203886 | HY-107738 | 95975-55-6 | MFCD01310757 | 312.453 | C21H28O2
Medchemexpress LLC Estrone 3-glucuronide sodium | 15087-01-1 | HY-W008917 | 98.8% | 468.47 | 5 MG
Estrone 3-glucuronide sodium is a metabolite of 17-Estradiol. It is used as a standard to estimate estrone conjugate (E1Cs) from urine samples by enzyme immunoassays (EIAs) and as a reference standard in assays that measure urinary E1C, a key marker for tracking the transition to the luteal phase.
- Used as a standard to estimate estrone conjugate (E1Cs) from urine samples by enzyme immunoassays (EIAs).
- Reference standard in assays that measure urinary E1C.
- Key marker for tracking the transition to the luteal phase.
Apexbio Technology LLC ACETAMINOPHEN-D3-1MG
Acetaminophen-d3 (CAS No 60902-28-5) is a deuterated form of acetaminophen frequently used in biomedical research especially within pharmacokinetic and drug metabolism studies Originating as a derivative of the widely used analgesic and antipyretic compound its primary mechanism involves inhibition of the cyclooxygenase (COX) enzymes primarily within the central nervous system This deuterated variant is valuable for studying metabolic pathways due to its stability and distinct mass allowing for precise tracking via mass spectrometry It demonstrates activity ranging from nanomolar to low micromolar levels in vitro Acetaminophen-d3 is commonly used in cell models animal studies and high-throughput drug screening assays to elucidate metabolic processes and interactions with other pharmaceuticals Experimental concentrations typically depend on the specific research design
Apexbio Technology LLC 25-HYDROXYVITAMIN-D3-D3-1MG
25-Hydroxyvitamin D3-d3 (CAS No 140710-94-7) is a stable isotope-labeled analog of 25-hydroxyvitamin D3 used primarily in biomedical research It belongs to the category of vitamin D metabolites and is often employed to study the metabolism and function of vitamin D in biological systems Its mechanism of action involves binding to the vitamin D receptor (VDR) influencing calcium and phosphate homeostasis and modulating immune responses Commonly this compound displays activity in the nanomolar to low micromolar range in vitro It is frequently used in cellular models to understand vitamin D metabolism and in animal studies to evaluate pharmacokinetics Additionally it serves as a reference in drug screening assays to assess analogs efficacy and potency Experimental concentrations typically depend on the specific research design
Medchemexpress LLC Skatole-d3 | 111399-60-1 | 134.19 | 1 MG
Skatole-d3 is the deuterium labeled Skatole. It is produced by intestinal bacteria and regulates intestinal epithelial cellular functions by activating aryl hydrocarbon receptors and p38. It is for research use only. Deuteration has gained attention due to its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Cayman Chemical 5 6-trns-VItamIn D3 10mg
An isomer of vitamin D3; increases tibia ash weight and bone mineralization in vitamin D-deficient chicks at 1, 3, and 10 UG/day; induces intestinal calcium transport and bone calcium mobilization in anephric rats fed a low-calcium and vitamin D-deficient diet at 25 UG/animal
Medchemexpress LLC Deapi-platycodin D3 | 67884-05-3 | 1 ML
Deapi-platycodin D3 is a triterpenoid saponin derived from the roots of Platycodon grandiflorum. This compound is intended for research use only.
- Purity: 98.86%
- Molecular weight: 1255.35
- Formula: C58H94O29
- Appearance: White to off-white solid
- Classification: Terpenoids, triterpenes
- Initial source: Plants, Campanulaceae, Platycodon grandiflorus (Jacq.) A. DC.
- Storage (solid): 4°C, protect from light
- Storage (in solvent): -80°C for 6 months; -20°C for 1 month (protect from light)
- Solubility (in vitro): DMSO 100 mg/mL (79.66 mM)
Medchemexpress LLC 7-methylguanosine-d3 | 00-00-0 | 98.5% | 301.29 g·mol⁻¹ | C11H13D3N5O5 | 5 MG
7-Methylguanosine-d3 is a deuterium-labeled stable isotope of 7-methylguanosine intended as a high-purity reference standard for analytical and biochemical applications. It is supplied in small-mass packages suitable for use in quantitative mass spectrometry, tracer studies, and method development. The unlabeled parent compound has reported activity against cNIIIB nucleotidase (IC50 = 87.8 ± 7.5 μM).
- High-purity deuterium-labeled isotopic standard for accurate mass spectrometry.
- Suitable as an internal standard for LC-MS or GC-MS quantitation.
- Useful for tracer studies and metabolic labeling experiments.
- Provided in small mass vials compatible with analytical workflows.
- Molecular formula C11H13D3N5O5; molecular weight 301.29 g·mol⁻¹.